Researchers at the Max Delbrueck Center for Molecular Medicine (MDC) have identified an epigenetic mechanism that appears to strongly influence healthy aging. It’s a protein […]
Prescribing opioids for a sprained ankle?
While ankle sprain injuries are common, a new report from Michigan Medicine suggests that the rate of opioids prescribed to those patients have become uncommonly […]
Data demonstrate efficacy of more flexible dose of regorafenib to relieve side-effects in mCRC patients
Medical oncologists administer anticancer drug regorafenib to try to improve overall survival in patients with metastatic colorectal cancer who have ceased to respond to standard […]
Gene mutation evolved to cope with modern high-sugar diets
The gene variant became more common in humans after cooking and farming became widespread, and might now help people avoid diabetes, according to the findings […]
Researchers study resistance to ‘protect’ anti-TB drug
In July last year, South Africa became the first country to roll out a new anti-tuberculosis drug in its national programme. This new drug, called […]
Epigenetic study provides new approaches to combination therapies for aggressive cancers
Epigenetic processes enable cells to respond to changes in their environment by regulating the activity of their genes. One of the proteins that plays a […]
Brain signaling proteins hit the road running: New study of brain neurotransmitter receptor has implications for drug discovery
Surprisingly complex movements in an important neurotransmitter receptor may help explain the brain’s unpredictable response to drugs, according to a new study. New research from […]
CRISPR base editors can induce wide-ranging off-target RNA edits: Team finds transcriptome-wide effects of two classes of base editors, develops variants with substantially less off-target impact
A Massachusetts General Hospital (MGH) research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA […]
AI identifies risk of cholesterol-raising genetic disease
A new algorithm can determine whether a patient is likely to have a cholesterol-raising genetic disease that can cause early, and sometimes fatal, heart problems, […]
Experimental drug delivers one-two punch to vision loss: Experiments show new therapy slows blood vessel leakage associated with diabetic macular edema and macular degeneration
In studies with lab-grown human cells and in mice, Johns Hopkins Medicine researchers have found that an experimental drug may be twice as good at […]
Psychedelic drug MDMA may reawaken ‘critical period’ in brain to help treat PTSD
Johns Hopkins neuroscientists have found that the psychedelic drug MDMA reopens a kind of window, called a “critical period,” when the brain is sensitive to […]
As if by magic: Program lights up cancer-causing mutations: LumosVar — a name inspired by Harry Potter — could help physicians provide genomic-based treatments for their patients
By conjuring the spell “Lumos!” wizards in the mythical world of Harry Potter could light up the tip of their magic wands and illuminate their […]
Gene behind long-recognized mitochondrial disease has highly varied effects
For more than two decades, mutations in a gene located in the DNA of mitochondria have been classified as a mitochondrial disease and linked to […]
New drug for Duchenne muscular dystrophy clears phase 1 clinical trial testing in boys
Patients with Duchenne muscular dystrophy (DMD) have few treatment options. Medications currently available or in development either target only a subset of DMD patients with […]