A non-invasive, patient-friendly imaging technique can help physicians make treatment decisions for breast cancer patients when diagnostic dilemmas arise. The ¹⁸F-FES PET scan-;approved by the U.S. Food and Drug Administration in 2020-;was shown to solve 87 percent of dilemmas, providing physicians with information for personalized treatment decision-making. This research was published in the September issue of The Journal of Nuclear Medicine.

A key characteristic of breast cancer is the estrogen receptor (ER), which is expressed by 79 percent of breast tumors. Breast tumors that are ER-positive are likely to respond to hormonal therapy. To assess the presence of the ER, a biopsy of a tumor or metastases is commonly performed. However, clinical dilemmas may arise when a biopsy cannot be performed safely or when discrepancies in ER expression is suspected between tumor lesions.

¹⁸F-FES PET has the potential to visualize the ER expression of all tumors across the body, and could provide helpful information regarding clinical dilemmas in breast cancer patients. In our study, we evaluated whether ER clinical dilemmas could be solved by ¹⁸F-FES PET findings."

Carolina P. Schröder, MD, PhD, medical oncologist, University Medical Center Groningen in The Netherlands

The retrospective study reviewed 100 ¹⁸F-FES PET scans that were performed on 83 patients with three types of clinical dilemmas. These dilemmas included the inability to determine the extent of disease with the standard workup, unclear ER status of the tumor, or the inability to determine which primary tumor caused the metastases.

The clinical dilemma was solved by ¹⁸F-FES PET in 87 percent of scans. In 93 percent of the solved cases, a treatment decision was based directly on the ¹⁸F-FES PET result. The frequency of solved dilemmas was not associated with the type of dilemma. However, the frequency of solved dilemmas was related to ER status, as dilemmas in ER-positive scans were more likely to be solved than in ER-negative scans.

"This is the largest study to show the value of ¹⁸F-FES PET in a 'real daily clinical practice,'" said Schröder. "These findings support the use of ¹⁸F-FES PET for optimal patient outcomes and may support broad implementation of ¹⁸F-FES PET in clinical practice."