Practitioner-supported, mindfulness-based cognitive therapy self-help (MBCT-SH) is superior to standard recommended treatment for mild-to-moderate depression, according to a study published online March 22 in JAMA Psychiatry.
Clara Strauss, Ph.D., D.Clin.Psy., from Sussex Partnership NHS Foundation Trust in Falmer, England, and colleagues examined whether MBCT-SH is superior to practitioner-supported cognitive behavioral therapy self-help (CBT-SH) at reducing depressive symptom severity at 16 weeks among 410 patients with mild-to-moderate depression. Copies of either an MBCT-SH or CBT-SH workbook were given to the participants, and they were also offered six support sessions with a trained practitioner.
The researchers found that at 16 weeks postrandomization, practitioner-supported MBCT-SH led to significantly greater reductions in depression symptom severity versus practitioner-supported CBT-SH (between-group difference of −1.5 Patient Health Questionnaire points). The probability of MBCT-SH being cost-effective exceeded 95 percent versus CBT-SH. Three serious adverse events were reported, but deemed not study-related.
“In conclusion, this study found that a novel intervention, practitioner-supported MBCT-SH, was clinically superior in targeting depressive symptom severity at postintervention and cost-effective compared with the criterion standard of practitioner-supported CBT-SH for adults experiencing mild-to-moderate depression,” the authors write. “If study findings are translated into routine practice, this would see many more people recovering from depression while costing health services less money.”
Clara Strauss et al, Clinical Effectiveness and Cost-Effectiveness of Supported Mindfulness-Based Cognitive Therapy Self-help Compared With Supported Cognitive Behavioral Therapy Self-help for Adults Experiencing Depression, JAMA Psychiatry (2023). DOI: 10.1001/jamapsychiatry.2023.0222
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