How obesity affects vitamin D metabolism

A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.

The study reveals that obese mice have very low levels of the enzyme in the liver that converts vitamin D into 25-hydroxyvitamin D (calcidiol), which is the major form of vitamin D in the blood. Therefore, it may be more effective to treat vitamin D insufficiency in obese individuals with calcidiol rather than with other forms of vitamin D.

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