Scientists have zeroed in on a structural protein as a new target for the diagnosis and treatment of depression, according to research recently published in JNeurosci.

The protein tubulin provides structure to cells and assists in many cellular processes, but it also plays a role in depression. A modified form of tubulin anchors the protein Gαs to lipid rafts, fatty structures floating in the cell membrane. In depressed people, Gαs gets stuck in lipid rafts and cannot trigger the production of cAMP, a molecule necessary for quick messaging in the brain. Imaging studies have shown that people with depression have less cAMP in their brains, which is remedied after successful treatment.

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