Sleep deprivation, which means getting too little high-quality sleep, is a serious health problem. More than one-third of people in the U.S. report getting less than the recommended minimum of seven hours sleep per night. Sleep deprivation has negative impacts on mental and physical health. Eye problems such as dryness and itching are commonly experienced after episodes of sleep deprivation, while long-term sleep deprivation comes with an increased risk for eye disease.

The cornea, which is the transparent tissue layer covering the eye, is essential for assuring health and function of the eye. The cornea is maintained by stem cells, which divide to replace dying cells and to repair small injuries. Corneal stem cell activity needs to be precisely tuned to assure an adequate output of new corneal cells, and dysregulation of corneal stem cells can lead to eye disease and impaired vision.

In a study recently published in Stem Cell Reports, researchers Wei Li, Zugou Liu and colleagues from Xiamen University, China and Harvard Medical School, U.S., evaluated how sleep deprivation impacts corneal stem cells. Their experiments in mice showed that short-term sleep deprivation increased the rate at which stem cells in the cornea multiplied. At the same time, sleep deprivation altered the composition of the protective tear film, reducing the tear film antioxidants in sleep-deprived mice. The researchers found that the tear film composition had a direct impact on corneal stem cell activity and, encouragingly, application of tear drops containing antioxidants reversed the excessive stem cell activity.

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